- Title
- The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations
- Creator
- Hiles, Sarah A.; Baker, Amanda L.; de Malmanche, Theo; McEvoy, Mark; Boyle, Michael; Attia, John
- Relation
- Journal of Behavioral Medicine Vol. 38, Issue 4, p. 609-619
- Publisher Link
- http://dx.doi.org/10.1007/s10865-015-9637-2
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2015
- Description
- This study investigated whether inflammation may explain the relationship between depression and incident cardiovascular hospitalisations. Participants (55-85 years) completed baseline depression and physical assessment. Those without self-reported cardiovascular events were followed prospectively for hospital admissions for angina, myocardial infarction and cerebral infarction (median 937 days). Across 5140 person-years of risk (N = 1692), there were 47 incident cardiovascular hospitalisations (2.8 %). Controlling for age and gender, interleukin (IL)-6, C-reactive protein (CRP), body mass index (BMI) and waist-to-hip ratio were associated with future cardiovascular events. Mediation analysis showed that CRP accounted for 8.1 % and IL-6 10.9 % of the effect of depression on cardiovascular events, and including the indirect effect in the model substantially reduced the direct relationship between depression and cardiovascular hospitalisations. BMI and waist-to-hip ratio accounted for indirect effects of 7.7 and 10.4 %, respectively. Inflammatory markers partly explain the association between depression and cardiovascular events, although other shared factors also likely contribute.
- Subject
- depression; inflammation; myocardial infarction; cerebral infarction; angina pectoris
- Identifier
- http://hdl.handle.net/1959.13/1334552
- Identifier
- uon:27318
- Identifier
- ISSN:0160-7715
- Rights
- The final publication is available at Springer via http://dx.doi.org/10.1007/s10865-015-9637-2
- Language
- eng
- Full Text
- Reviewed
- Hits: 5441
- Visitors: 3647
- Downloads: 825
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Author final version | 491 KB | Adobe Acrobat PDF | View Details Download |